There are several instances when IVF fails, even when the embryo
might be good. It is not uncommon to see patients who have undergone 3, 5 or
even 8 cycles of IVF/ICSI.
In such circumstances, it is very important to evaluate to find
out the reason. Of course, the quality of egg/sperm is important and if those
are bad, the only option is to go for donor egg or donor sperm accordingly.
In case gamates and embryo are good, the reason could be failure
of implantation. Implantation is the process by which communication happens
between the embryo and the inner lining of the uterus. It happens through some
chemicals which results in adherence of embryo and subsequent growth in the
lining.
Endometrial Receptivity
Test, now introduced in India can diagnose if the uterine lining is ready for
the embryo
implantation to take place. This occurs around days 19-21 in each menstrual
cycle of a fertile woman
This is a crucial step for pregnancy. No matter how good
embryo is, if the test is negative, it will not result in pregnancy. Thus, it
helps in finding the cause in repeated ART failures. By changing the dates of
the test, one may be able to find a different time frame when the uterus will
be receptive to the embryo. This helps in changing the embryo transfer date.
The method for the test is quite simple and is done in an
outpatient setting by collecting a small sample of the endometrium and sending
it for analysis. It is cost effective as it will avoid unnecessary repetition
of IVF.
Endometrial receptivity assay
ERA - success story
She came to me for donor egg , at 37 yrs , she
had 5 failed IVF cycles , history of PCOD and teratozoospermia (husband) . After
a scientific analysis, we felt she needed to have hysterolaparoscopy, which was
surprisingly never suggested . Flimsy tubal adhesions were released and ovarian
drilling was done. We also performed endometrial receptivity test ( ERA ).
The test was positive and she was very much reassured by the fact that she can
conceive.
While they were waiting for an IVF with donor egg next cycle , I
suggested IUI. To our great surprise she conceived, had a smooth pregnancy
and Caesarian at term. The mother’s joy knew no bounds when she held her beautiful
baby girl. All it took was scratching
the uterus !! Psychology may also play an important role, which we ignore most
of the time ....
Dr. Anita Mani
Infertility Specialist at Gift IVF Centre
Infertility Specialist at Gift IVF Centre
anitadane@gmail.com
GIFT IVF CENTER
#4, 3R Plaza HAL 2nd Stage,
100 Feet Road,Indiranagar,
Bangalore India- 560008
Contact: +91-8050888880
GIFT IVF CENTER
Near Cochin International Airport Jn.
Athani, Ernakulam Dt, Kerala, India-683585
Athani, Ernakulam Dt, Kerala, India-683585
Contact: +91-974 5494804
Email: info@giftivf.com
Web site: www.giftivf.com
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