FOETAL KARYOTYPING PROVES TRIPLOIDY IN RECURRENT MISCARRIAGE WITH DONORSPERM IUI29 year old patient came with a history of 9 donor sperm IUI and 2 miscarriages. Her husband had azoospermia.
Pregnancy was achieved after another donor sperm IUI, but unfortunately another miscarriage followed , there was no fetal heart at 10 weeks .
Foetal karyotyping by FISH, was done by sending fresh - products of conception after evacuation of uterus to find out if the baby was abnormal. FISH (fluorescence in situ hybridization) is a technique that is used to detect and localize the presence or absence of specific DNA sequences on chromosomes. The result came as triploidy, fetuses with Triploidy or Triploid Syndrome have an extra set of chromosomes in their cells. This proved that, the eggs may be abnormal in her, so that even after donor sperm IUI, either she fails to conceive ( due to early embryo loss)or miscarriage happens .
Though not proven, an Interesting fact is that often infertile men those who don't have enough sperm count choose infertile women. Whether it is by natural selection or if the healthy sperms increase fertility in women is debatable and research might be interesting